Washington DC [USA], Jul 25 (ANI): Researchers at the University of Virginia School of Medicine have identified a critical cause of chronic inflammation that accelerates aging. This discovery can set us back and live longer and healthier lives, as well as prevent age-related diseases such as fatal heart disease and serious mental disorders that rob us of our abilities. So what causes this harmful inflammation? The answer is poor calcium signaling in the mitochondria of some immune cells. Mitochondria are the energy generators of all cells and are dependent on calcium signaling. UVA health researchers, by Bimal N. Desai, PhD, discovered that the mitochondria of immune cells called macrophages lose their ability to absorb and use calcium with age. This, according to researchers, leads to chronic inflammation that causes many diseases that plague our stomachs. Researchers believe that increasing calcium through mitochondrial macrophages can prevent harmful inflammation and its effects. Since macrophages live in every part of our body, including the brain, using the right drugs to target "tissue-resident macrophages" can slow down age-related neurodegenerative diseases. "I think we've made a big breakthrough in understanding the basis of stomach-related pain," said Desai, of UVA's Department of Medicine and UVA's Carter Immunology Center. "This discovery leads to new therapeutic strategies to neutralize the inflammatory factors that are at the heart of many cardiometabolic and neurodegenerative diseases."  Inflammation of aging - "Inflammation"  Macrophages are white blood cells that play an important role in the immune system and, therefore, in our health. They swallow dead or dying cells, allowing our body to get rid of cell debris and guard against viruses and foreign invaders. In the latter role, they act as important sentinels for our immune system, calling for help from other immune cells when needed. Scientists know that macrophages become less efficient with age, but the reason is not clear. Desai's new research suggests an answer. Desai and his team say their research has identified a "keystone" mechanism for age-related changes in macrophages. These changes, scientists say, make macrophages more susceptible to chronic inflammation, which is chronic at best. And when immune cells are faced with an invader or tissue damage, they can become active. This leads to what is called "inflammation" - chronic inflammation that leads to aging. In addition, the UVA health scientists think that the process they discovered will be true not only for macrophages, but for many other immune cells involved in the bone marrow. This means that we can also make these cells work better, which can improve our immune system in old age, when we are more susceptible to infections. Another step  Fixing "inflammation" won't be as easy as taking a calcium supplement. The problem is not a lack of calcium so much as an inability of macrophages to use it properly. But Deaai's new detection has been determined by a machine that puts the process, so we can do so you can find the way to make this machine to go. The research is doing well, the interface of computer-in-law information, exclusion of the Phil Who's Phil Who's Super . " "Now, going forward, we need a serious effort to understand the wiring that controls this mitochondrial system in different types of macrophages, and then use the power to manipulate this wiring for biomedical effects." (ANI)